Priority 12 from the Scoliosis PSP

UNCERTAINTY: How is scoliosis affected by hormonal changes in women (puberty, pregnancy and the menopause) and does this have implications for treatment using HRT? (JLA PSP Priority 12)
Overall ranking	12
JLA question ID	0059/12
Explanatory note	Not available for this PSP
Evidence	Previous related research studies - None identified
Health Research Classification System category	Musculoskeletal

Extra information provided by this PSP
Original uncertainty examples	There appears to be links that hormonal changes in women can trigger Scoliosis. Prove. Also can hormone therapies help lessen or stop a progressive curve? ~ Would coming off HRT and less physical work contribute to the worsening of the scoliosis (which may well have been there in a much lesser degree before it became very obvious)? ~ What effect can pregnancy have on an otherwise stable case of mild scoliosis?

Extra information provided by this PSP

Original uncertainty examples

There appears to be links that hormonal changes in women can trigger Scoliosis. Prove. Also can hormone therapies help lessen or stop a progressive curve? ~ Would coming off HRT and less physical work contribute to the worsening of the scoliosis (which may well have been there in a much lesser degree before it became very obvious)? ~ What effect can pregnancy have on an otherwise stable case of mild scoliosis?

PSP information
PSP unique ID	0059
PSP name	Scoliosis
Total number of uncertainties identified by this PSP.	54 (To see a full list of all uncertainties identified, please see the PSP final report held on the JLA website)
Date of priority setting workshop	4 November 2017