Priority 4 from the Miscarriage PSP

UNCERTAINTY: To what extent do pre-existing medical conditions cause miscarriage? (e.g. vitamin deficiencies, diabetes, previous infertility, endometriosis, polycystic ovarian syndrome, menstrual irregularities, cervical factors, uterine anomalies, polyps, immunological factors or previous pregnancy complications e.g. caesarean section or preterm birth) (JLA PSP Priority 4)
Overall ranking	4
JLA question ID	0053/4
Explanatory note	Examples of original survey submissions: What health predispositions in women increase the risk of miscarriage?; To what extent does PCOS affect the risk of miscarriage? What factors reduce that risk?; Are there any associations between preterm birth and miscarriage?
Evidence	Balogun OO, da Silva Lopes K, Ota E, Takemoto Y, Rumbold A, Takegata M, Mori R. Vitamin supplementation for preventing miscarriage. Cochrane Database of Systematic Reviews 2016, Issue 5. Art. No.: CD004073. DOI: 10.1002/14651858.CD004073.pub4. Kyrgiou M, Mitra A, Arbyn M, Paraskevaidi M, Athanasiou A, Martin-Hirsch PPL, Bennett P, Paraskevaidis E. Fertility and early pregnancy outcomes after conservative treatment for cervical intraepithelial neoplasia. Cochrane Database of Systematic Reviews 2015, Issue 9. Art. No.: CD008478. DOI: 10.1002/14651858.CD008478.pub2.
Health Research Classification System category	Reproduction

Extra information provided by this PSP
Submitted by	7 professionals ~ 43 women ~ 1 family, friends or colleagues

PSP information
PSP unique ID	0053
PSP name	Miscarriage
Total number of uncertainties identified by this PSP.	58 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop	14 October 2016