Priority 6 from the Hyperemesis Gravidarum PSP
| UNCERTAINTY: What are the immediate and long term effects of the various medications/treatments on the developing foetus throughout the various stages of pregnancy and in varying doses or combinations of treatments? (JLA PSP Priority 6) | |
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| Overall ranking | 6 |
| JLA question ID | 0090/6 |
| Explanatory note | Not available for this PSP |
| Evidence |
Various studies and reviews of individual medications for particular exposure periods. For example, SR found: "first trimester ondansetron exposure is not associated with an overall statistically significant increased risk of congenital malformations or cardiovascular defects." ref: Balayla, J.; D'Alton, M. E. 2016 First trimester ondansetron exposure and the risk of major congenital malformations and heart defects: A systematic review and meta-analysis. American Journal of Obstetrics and Gynecology - Volume 1, Issue 0, pp. S177. This doesn't answer the question on whether ondansetron is safe throughout pregnancy, third trimester or in what doses or in combination with other medication |
| Health Research Classification System category | Reproductive health and childbirth |
| Extra information provided by this PSP | |
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| Original uncertainty examples | Do any of the medicines harm the baby? ~ Does the type, dose and duration of medication have different effects on the baby depending on the time of the pregnancy the medication is used. For example, does ondansetron have a different (potential) effect on the baby if this is taken in the first trimester vs the last trimester? ~ Is this drugs cocktail really the best thing for baby? |
| Submitted by | Patients x 80 ~ Healthcare professionals x 19 ~ Carers x 2 ~ Offspring x 9 ~ Unknown x 3 |
| PSP information | |
|---|---|
| PSP unique ID | 0090 |
| PSP name | Hyperemesis Gravidarum |
| Total number of uncertainties identified by this PSP. | 65 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website) |
| Date of priority setting workshop | 9 October 2019 |