Priority 13 from the Hyperemesis Gravidarum PSP

UNCERTAINTY: What is the risk that hyperemesis gravidarum will reoccur in a subsequent pregnancy? Does hyperemesis gravidarum get progressively worse with subsequent pregnancies and what are the risk factors for reoccurrence? (JLA PSP Priority 13)
Overall ranking	13
JLA question ID	0090/13
Explanatory note	Not available for this PSP
Evidence	5 papers vary from 15-81%, meta analysis not possible.
Health Research Classification System category	Reproductive health and childbirth

Extra information provided by this PSP
Original uncertainty examples	What is the recurrence rate? ~ Will I definitely have HG again in future pregnancies? ~ Does Hyperemesis get worse with each pregnancy? What are the chances that you get HG with the following pregnancy/pregnancies? ~ If you have HG, how likely are you to get it a second time? ~ What are the chances of getting HG again after suffering with it during my first pregnancy? ~ Is HG more severe dependant on partner? ~ Are you likely to get HG again if you use sperm from a different man/donor? ~ How much of an influence does the sperm have?
Submitted by	Patients x 191 ~ Healthcare professionals x 16 ~ Carers x 10 ~ Offspring x 17 ~ Unknown x 6

Extra information provided by this PSP

Original uncertainty examples

What is the recurrence rate? ~ Will I definitely have HG again in future pregnancies? ~ Does Hyperemesis get worse with each pregnancy? What are the chances that you get HG with the following pregnancy/pregnancies? ~ If you have HG, how likely are you to get it a second time? ~ What are the chances of getting HG again after suffering with it during my first pregnancy? ~ Is HG more severe dependant on partner? ~ Are you likely to get HG again if you use sperm from a different man/donor? ~ How much of an influence does the sperm have?

Submitted by

Patients x 191 ~ Healthcare professionals x 16 ~ Carers x 10 ~ Offspring x 17 ~ Unknown x 6

PSP information
PSP unique ID	0090
PSP name	Hyperemesis Gravidarum
Total number of uncertainties identified by this PSP.	65 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop	9 October 2019