Priority 15 from the Electronic Cigarettes PSP

UNCERTAINTY: What are the short term effects of vaping? Compared to smoking, ex-smokers, never-smokers and NRT use? (JLA PSP Priority 15)
Overall ranking	15
JLA question ID	0087/15
Explanatory note	Not available for this PSP
Evidence	Although PHE do state that the evidence suggests e-cigarettes are 95% safer than smoking, with the recent deaths in America from vaping more research and evidence would give weight to this position statement, particularly if we can have more research on a broader range of biomarkers. Liu, Xing, et al. "Efficiency and adverse events of electronic cigarettes: A systematic review and meta-analysis (PRISMA-compliant article)." Medicine 97.19 (2018). Looks at adverse events in smokers. Doesn't compare to smoking, ex-smoking, non-smokers. Would be good to have a fresh look at this. There are a few well conducted studies e.g.: Ann Intern Med. 2017 Mar 21;166(6):390-400. doi: 10.7326/M16-1107. Epub 2017 Feb 7. Nicotine, Carcinogen, and Toxin Exposure in Long-Term E-Cigarette and Nicotine Replacement Therapy Users: A Cross-sectional Study.
Health Research Classification System category	Generic health relevance

Extra information provided by this PSP
Original uncertainty examples	Short term health effects? ~ What are the short-term harms of vaping compared to tobacco smoking
Submitted by	34 x Healthcare Professionals, 124 x Patients

PSP information
PSP unique ID	0087
PSP name	Electronic Cigarettes
Total number of uncertainties identified by this PSP.	52 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop	20 September 2019