Priority 9 from the Cavernoma PSP
| UNCERTAINTY: What features of brain cavernoma lead to the development of epilepsy, or influence the severity of existing epilepsy? (JLA PSP Priority 9) | |
|---|---|
| Overall ranking | 9 |
| JLA question ID | 0035/9 |
| Explanatory note | Not available for this PSP |
| Evidence |
Up to date systematic review: Rosenow F*, Alonso-Vanegas MA, Baumgartner C, Blümcke I, Carreño M, Gizewski ER, et al. Cavernoma-related epilepsy: Review and recommendations for management—Report of the Surgical Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia. 2013;54(12): 2025-35. DOI: 10.1111/epi.12402 Out of date systematic review: Moran NF. Fish DR. Kitchen N. Shorvon S. Kendall BE. Stevens JM. Supratentorial cavernous haemangiomas and epilepsy: a review of the literature and case series. Neurosurg Psychiatr. 1999; 66(5):561-8. https://jnnp.bmj.com/content/66/5/561.long Reference to an up to date relevant and reliable systematic review which does not refer to uncertainty but could be extended: Al-Shahi Salman R. The outlook for adults with epileptic seizure(s) associated with cerebral cavernous malformations or arteriovenous malformations. Epilepsia. 2012;53 (SUPPL. 4):34-42. doi: 10.1111/j.1528-1167.2012.03611.x. |
| Health Research Classification System category | Neurological |
| Extra information provided by this PSP | |
|---|---|
| Original uncertainty examples | Not available |
| Comparison | Aetiology; Prognosis |
| Submitted by | From an existing research recommendation |
| Outcomes to be measured | Change of symptoms; health related quality of life |
| PSP information | |
|---|---|
| PSP unique ID | 0035 |
| PSP name | Cavernoma |
| Total number of uncertainties identified by this PSP. | 54 |
| Date of priority setting workshop | 23 September 2015 |