Priority 1 from the Cavernoma PSP
| UNCERTAINTY: Does treatment (with neurosurgery or sterotactic radiosurgery) or no treatment improve outcome for people diagnosed with brain or spine cavernoma? (JLA PSP Priority 1) | |
|---|---|
| Overall ranking | 1 |
| JLA question ID | 0035/1 |
| Explanatory note | Not available for this PSP |
| Evidence |
Wang X, Mei G, Liu X, Dai J, Pan L, Wang E. The role of stereotactic radiosurgery in cavernous sinus hemangiomas: a systematic review and meta‐analysis. J Neuro‐Oncol. 2012;107(2):239‐45. doi: 10.1007/s11060-011-0753-8. Epub 2011 Nov 16. Lu XY, Sun H, Xu JG, Li QY. Stereotactic radiosurgery of brainstem cavernous malformations: a systematic review and meta‐analysis. J Neurosurg. 2014;120(4):982‐7. doi: 10.3171/2013.12.JNS13990. Epub 2014 Feb 7. Badhiwala J.H. Farrokhyar F. Alhazzani W. Yarascavitch B. Ed Aref M. Algird A, et al. Surgical outcomes and natural history of intramedullary spinal cord cavernous malformations: a single-center series and meta-analysis of individual patient data. Journal of Neurosurgery: Spine. 2014;21 (4):662-76. doi: 10.3171/2014.6.SPINE13949. Epub 2014 Jul 25. Poorthuis M. Samarasekera N. Kontoh K. Stuart I. Cope B. Kitchen N. Al-Shahi Salman R. Comparative studies of the diagnosis and treatment of cerebral cavernous malformations in adults: Systematic review. Acta Neurochirurg. 2013;155 (4):643-9. doi: 10.1007/s00701-013-1621-4. Epub 2013 Jan 31. Poorthuis MH, Klijn CJ, Algra A, Rinkel GJ, Al‐Shahi Salman R. Treatment of cerebral cavernous malformations: a systematic review and meta‐regression analysis. J Neurol Neurosurg Psychiatr. 2014; 85(12):1319-23. doi: 10.1136/jnnp-2013-307349. Epub 2014 Mar 25. |
| Health Research Classification System category | Neurological |
| Extra information provided by this PSP | |
|---|---|
| Original uncertainty examples | Not available |
| Comparison | Surgery; Service delivery |
| Submitted by | 120 patients. 28 clinicians. |
| Outcomes to be measured | Prognosis: change in symptoms, or change in management of symptoms; adverse effects or complications; patient satisfaction; health related quality of life; service related issues; and health related cost |
| PSP information | |
|---|---|
| PSP unique ID | 0035 |
| PSP name | Cavernoma |
| Total number of uncertainties identified by this PSP. | 54 |
| Date of priority setting workshop | 23 September 2015 |