Priority 18 from the Bipolar PSP

UNCERTAINTY:What are the risks and benefits to mother and baby of medication for bipolar (e.g. during pregnancy, childbirth and breastfeeding)? (JLA PSP Priority 18)
Overall ranking	18
JLA question ID	0041/18
Explanatory note	Not available for this PSP.
Evidence	None identified
Health Research Classification System category	Mental Health

Extra information provided by this PSP
Original uncertainty examples	For full examples, see Category ID R2 on spreadsheet. Can postpartum psychosis/ childbirth in some women trigger the onset of bipolar? ~ can a baby be affected by the moods of a bipolar mother during pregnancy? ~ Regarding my medication, what do I have to do if I want to get pregnant? ~ we need more reserach on mood stabilizers during pregnancy. At the moment quetiapine is the default choice in most countries but despite all the marketing surrounding it, I dont find it that useful in clinical practice. Many women drop from treatment at pregnancy and these has consequences for both women and children. To know more about safe treatments in pregnancy would be very useful. ~ Breastfeeding and medication? ~ will I get antinatel depression? ~ Advice on coming off mood stabilisers such as sodium valproate before pregnancy. ~ My friend had to come off them in order to have a baby - what risks did the drugs have on an unborn child and what risks did she face with coming off her treatment?
Submitted by	Patients x 59 ~ Carers x 26 ~ Health Professionals x 8 ~ Others x 3

Extra information provided by this PSP

Original uncertainty examples

For full examples, see Category ID R2 on spreadsheet. Can postpartum psychosis/ childbirth in some women trigger the onset of bipolar? ~ can a baby be affected by the moods of a bipolar mother during pregnancy? ~ Regarding my medication, what do I have to do if I want to get pregnant? ~ we need more reserach on mood stabilizers during pregnancy. At the moment quetiapine is the default choice in most countries but despite all the marketing surrounding it, I dont find it that useful in clinical practice. Many women drop from treatment at pregnancy and these has consequences for both women and children. To know more about safe treatments in pregnancy would be very useful. ~ Breastfeeding and medication? ~ will I get antinatel depression? ~ Advice on coming off mood stabilisers such as sodium valproate before pregnancy. ~ My friend had to come off them in order to have a baby - what risks did the drugs have on an unborn child and what risks did she face with coming off her treatment?

Submitted by

Patients x 59 ~ Carers x 26 ~ Health Professionals x 8 ~ Others x 3

PSP information
PSP unique ID	0041
PSP name	Bipolar
Total number of uncertainties identified by this PSP.	363 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop	14 June 2016