Priority 1 from the Asthma PSP

UNCERTAINTY:
  1. a) What are the adverse effects associated with long term use of short and long acting bronchodilatorsÍž inhaled and oral steroidsÍž and combination and additive therapies in adults? (N.B this includes children aged 12 years old and over)?

    b) What are the adverse effects associated with long term use of short and long acting bronchodilatorsÍž inhaled and oral steroidsÍž and combination and additive therapies in children?

(JLA PSP Priority 1)
Overall ranking 1
JLA question ID 0001/1
Explanatory note Relevant reliable up-to-date systematic reviews do not address continuing uncertainties about treatment effects
Evidence Walters EH, Walters J, Gibson P, Jones PW. Inhaled short acting beta2-agonist use in chronic asthma: regular versus as needed treatment. Cochrane Database of Systematic Reviews 2003, Issue 1. Art. No.: CD001285. DOI: 10.1002/14651858.CD001285
Health Research Classification System category Respiratory
Extra information provided by this PSP
Incomplete trials at time of PSP None identified
Relevant Age Any
Submitted by Patients
Outcomes to be measured Adverse events
PSP information
PSP unique ID 0001
PSP name Asthma
Total number of uncertainties collated by this PSP from surveys 413 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop March 2007